Cyclobenzaprine StatPearls NCBI Bookshelf

Cyclobenzaprine is best used in short-term treatment but may be used intermittently or long-term for chronic pain. A post-marketing surveillance program was carried out in 7607 patients with acute musculoskeletal disorders, and included 297 patients treated with FLEXERIL 10 mg for 30 days or longer. The overall effectiveness of FLEXERIL was similar to that observed in the double-blind controlled studies; the overall incidence of adverse effects was less (see ADVERSE REACTIONS). In case of acute cyclobenzaprine overdose, emergency medicine physicians and triage nurses should stabilize the patient. If EKG demonstrates QRS prolongation, the clinician should initiate sodium bicarbonate therapy. In severe overdose, ventricular arrhythmias and seizures may require MICU-level of care under the supervision of a critical care physician.

Our writers and reviewers are experienced professionals in medicine, addiction treatment, and healthcare. AddictionResource fact-checks all the information before publishing and uses only credible and trusted sources when citing any medical data. The Verified badge on our articles is a trusted sign of the most comprehensive scientifically-based medical content. If you have any concern that our content is inaccurate or it should be updated, please let our team know at [emailprotected]. Other drugs with moderate interactions like that of alcohol, weed, and Ibuprofen include Benadryl (Diphenhydramine), Gabapentin (Neurontin), Ambien (Zolpidem), and Xanax (Alprazolam). These drugs may heighten the risk of side effects such as drowsiness, disorientation or lightheadedness, and mental impairment.

Interactions

If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice. Using drinks containing alcohol can increase your risk of dizziness, drowsiness, and decreased alertness from cyclobenzaprine. Elderly patients seem to tolerate cyclobenzaprine less and may develop hallucinations as well as significant anticholinergic side effects, such as sedation. The use of significant lower dosing schedules in elderly patients may be prudent. The most common adverse reactions to cyclobenzaprine are somnolence, dry mucous membranes, dizziness, and confusion.

• The kidneys of older adults may not work as well as they used to.
• Concomitant use of monoamine oxidase (MAO) inhibitors or within 14 days after their discontinuation.
• Elderly patients seem to tolerate cyclobenzaprine less and may develop hallucinations as well as significant anticholinergic side effects, such as sedation.
• However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects.

Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include IBM Watson Micromedex (updated 3 Sep 2023), Cerner Multum™ (updated 28 Aug 2023), ASHP (updated 10 Aug 2023) and others.

Less commonly, tachycardia, dysarthria, disorientation, and hallucinations have been reported [2]. This is not a complete list of side effects and others may occur. Avoid taking MAO inhibitors (isocarboxazid, linezolid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine) during treatment with this medication.

BACK AND NECK PAIN

Therefore, this drug should only be used in pregnancy if clearly needed. Many insurance companies require prior authorization for this drug. This means your doctor will need to get approval from your insurance company before your insurance company will pay for the prescription. You should not need a new prescription for this medication to be refilled.

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Do not start, stop, or change the dosage of any medicines without your doctor’s approval. It is structurally similar to the tricyclic antidepressants and adverse effects similar to those seen with the tricyclic antidepressants are therefore to be expected. Patients with low back pain or fibromyalgia may benefit from treatment with cyclobenzaprine. Recent evidence showed similar effectiveness at half of its manufacturer recommended dose (5 mg), but with can you take trazodone and flexeril together fewer adverse effects.33 It may optimally be used in younger patients with limited or no medical conditions. Higher doses of cyclobenzaprine or tizanidine would be appropriate to promote sedation in cases of more severe discomfort or perceived muscular spasm. Although there appears to be insufficient data on metaxalone and methocarbamol, these may be useful in patients who cannot tolerate the sedative properties of cyclobenzaprine or tizanidine.

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The combination of Cyclobenzaprine and alcohol, for instance, may result in tolerance, dependency, and abuse — this is also true for other drug combinations. Furthermore, it is important to consider how long Flexeril lasts. Nevertheless, recovery is possible for people struggling with substance addiction. The first step to take would be contacting the drug abuse rehab representatives for assistance. There are many addiction recovery programs available to get rid of the menace of dependence.

Selection of a skeletal muscle relaxant should be individualized to the patient. If there are tender spots over the muscle or trigger points on physical examination, a skeletal muscle relaxant is a reasonable adjunct to analgesic treatment of low back pain. Skeletal muscle relaxants may also be used as an alternative to NSAIDs in patients who are at risk of gastrointestinal or renal complications. This medicine will add to the effects of alcohol and other CNS depressants (medicines that slow down the nervous system, possibly causing drowsiness).

Call 911 or go to the nearest emergency room if your symptoms are severe. Do not take this drug again if you’ve ever had an allergic reaction to it. If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk with your doctor or pharmacist. It is also possible for serious cyclobenzaprine side effects to occur, like seizures, heart arrhythmias, heart attack, or stroke.